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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
45.15
Human Site:
S538
Identified Species:
70.95
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
S538
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Chimpanzee
Pan troglodytes
XP_528129
863
96543
S538
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
S604
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
S537
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Rat
Rattus norvegicus
NP_387500
862
96552
S537
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
S538
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Chicken
Gallus gallus
XP_424376
859
96866
S534
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Frog
Xenopus laevis
P30664
863
97105
S538
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
E442
A
A
K
P
D
V
Y
E
R
L
S
S
A
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
S540
Q
Y
T
S
G
R
G
S
S
A
V
G
L
T
A
Honey Bee
Apis mellifera
XP_624670
636
71159
E328
F
T
T
L
V
E
I
E
K
G
K
T
K
E
P
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
E451
D
E
F
D
K
M
R
E
D
D
R
V
A
I
H
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
S585
Q
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
G408
G
K
G
S
S
G
V
G
L
T
A
A
V
M
R
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
S596
V
Y
T
S
G
K
G
S
S
A
V
G
L
T
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
6.6
N.A.
93.3
6.6
0
100
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
6.6
N.A.
100
13.3
0
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
93.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
93.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
0
0
0
74
7
7
14
0
80
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
7
7
0
0
0
7
7
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
7
0
20
0
0
0
0
0
7
0
% E
% Phe:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
74
7
74
7
0
7
0
74
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% I
% Lys:
0
7
7
0
7
67
0
0
7
0
7
0
7
0
0
% K
% Leu:
0
0
0
7
0
0
0
0
7
7
0
0
74
7
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
7
% P
% Gln:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
7
0
7
0
7
0
0
0
7
% R
% Ser:
0
0
0
80
7
0
0
74
74
0
7
7
0
0
0
% S
% Thr:
0
7
80
0
0
0
0
0
0
7
0
7
0
74
0
% T
% Val:
7
0
0
0
7
7
7
0
0
0
74
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
74
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _